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John Wayne Casserole

John Wayne Casserole is a layered ground beef casserole with a biscuit crust, seasoned hamburger and vegetable filling, and a creamy, cheesy topping. It's a hearty and satisfying casserole with a kick!
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Prep Time: 30 minutes
Cook Time: 50 minutes
Servings: 8
Calories: 646kcal

Ingredients
 

  • 16 oz. can large buttermilk biscuits
  • Vegetable oil (to coat)
  • 1 ½ lbs. ground beef
  • 1 green bell pepper (diced)
  • 1 medium red onion (diced)
  • 2 teaspoons chili powder
  • 2 teaspoons cumin
  • 1 teaspoon garlic powder
  • ¾ cup sour cream
  • ¼ cup mayonnaise
  • 2 cups shredded cheddar cheese
  • 3 roma tomatoes (sliced)
  • 1 jalapeno (minced)
  • Salt and pepper (to taste)

Instructions

  • Preheat the oven to 350˚ F. Grease a 9 x 13 inch casserole dish.
  • Open the can of biscuits and separate into individual pieces. Gently press the biscuits across the bottom and partially up the sides of the casserole dish. Bake for 10-12 minutes, or until the biscuits are light golden brown, then remove from the oven.
  • Meanwhile, heat the oil in a skillet over medium high heat. Add the ground beef, onion, and bell pepper and brown until onions and peppers are softened and no pink remains in the beef. Drain all but 2 tablespoons of excess fat from the pan.
  • Add the chili powder, cumin, garlic powder, salt and pepper to the cooked ground beef. Stir well to distribute the spices evenly and allow them to infuse the meat.
  • In a separate bowl, combine the sour cream, mayonnaise and ½ of cheese, blending them together until smooth and creamy.
  • Assemble the layers. Distribute the ground beef mixture evenly over the cooked biscuits. Place the sliced tomatoes on top of the beef mixture. Pour the sour cream and mayonnaise mixture over the tomatoes, forming a smooth layer. Finish with the remaining shredded cheese.
  • Bake for 25-30 minutes or until the cheese is golden and bubbling. Remove from the oven and garnish with diced jalapenos.

Notes

Leftover casserole can be stored, covered, in the fridge for 3-4 days.
To make ahead of time, follow the recipe instructions through step 6. Allow the casserole to cool then cover and refrigerate until ready to bake. To freeze, double wrap the casserole in saran wrap and foil and freeze for 3 months. Thaw overnight in the fridge before baking.
Course Main Course
Cuisine American
Keyword ground beef biscuit casserole, hamburger biscuit casserole, john wayne casserole

Nutrition

Calories: 646kcal | Carbohydrates: 33g | Protein: 26g | Fat: 46g | Saturated Fat: 16g | Polyunsaturated Fat: 8g | Monounsaturated Fat: 16g | Trans Fat: 1g | Cholesterol: 105mg | Sodium: 843mg | Potassium: 535mg | Fiber: 2g | Sugar: 5g | Vitamin A: 846IU | Vitamin C: 18mg | Calcium: 279mg | Iron: 4mg